Efficacy of weight loss drugs on obesity and cardiovascular risk factors in obese adolescents: a meta‐analysis of randomized controlled trials
Identifieur interne : 007304 ( Main/Exploration ); précédent : 007303; suivant : 007305Efficacy of weight loss drugs on obesity and cardiovascular risk factors in obese adolescents: a meta‐analysis of randomized controlled trials
Auteurs : S. Czernichow [Australie, France] ; C. M. Y. Lee [Australie] ; F. Barzi [Australie] ; J. R. Greenfield [Australie] ; L. A. Baur [Australie] ; J. Chalmers [Australie] ; M. Woodward [Australie] ; R. R. Huxley [Australie]Source :
- Obesity Reviews [ 1467-7881 ] ; 2010-02.
Descripteurs français
- Wicri :
- topic : Santé publique.
English descriptors
- KwdEn :
- Adolescents obesity reviews, Adult populations, Adverse effects, Adverse event, Attrition rate, Authors journal compilation, Berkowitz, Blood pressure, Body mass index, Cardiovascular, Cardiovascular risk factors, Caucasian adolescents, Cochrane library, Control group, Control groups, Czernichow, Diastolic blood pressure, Excess weight, George institute, Heterogeneity, Insulin levels, International association, International health, Larger studies, Limited evidence, Mmhg, Mmol, Obese, Obese adolescents, Obesity, Obesity reviews, Orlistat, Orlistat ozkan, Orlistat therapy, Overall attrition rate, Overall estimate, Overweight adolescents, Placebo, Placebo group, Placebo groups, Potential publication bias, Public health, Publication bias, Pulse rate, Quantitative estimates, Randomized, Randomized trials, Relevant articles, Relevant references, Risk factors, Search strategy, Sibutramine, Sibutramine berkowitz, Small amount, Small increase, Standard deviation, Standard deviations, Statistical heterogeneity, Systolic blood pressure, Therapeutic lifestyle change, Total cholesterol, True effect, Waist circumference, Weight decrease, Weight loss, Weight loss agents, Weight loss drug, Weight loss drugs.
- Teeft :
- Adolescents obesity reviews, Adult populations, Adverse effects, Adverse event, Attrition rate, Authors journal compilation, Berkowitz, Blood pressure, Body mass index, Cardiovascular, Cardiovascular risk factors, Caucasian adolescents, Cochrane library, Control group, Control groups, Czernichow, Diastolic blood pressure, Excess weight, George institute, Heterogeneity, Insulin levels, International association, International health, Larger studies, Limited evidence, Mmhg, Mmol, Obese, Obese adolescents, Obesity, Obesity reviews, Orlistat, Orlistat ozkan, Orlistat therapy, Overall attrition rate, Overall estimate, Overweight adolescents, Placebo, Placebo group, Placebo groups, Potential publication bias, Public health, Publication bias, Pulse rate, Quantitative estimates, Randomized, Randomized trials, Relevant articles, Relevant references, Risk factors, Search strategy, Sibutramine, Sibutramine berkowitz, Small amount, Small increase, Standard deviation, Standard deviations, Statistical heterogeneity, Systolic blood pressure, Therapeutic lifestyle change, Total cholesterol, True effect, Waist circumference, Weight decrease, Weight loss, Weight loss agents, Weight loss drug, Weight loss drugs.
Abstract
Weight loss drugs have been developed to reduce the comorbidities associated with excess weight. We conducted a meta‐analysis of the efficacy of orlistat and sibutramine on weight, body mass index, waist circumference and cardiovascular risk factors in overweight adolescents. MEDLINE and the Cochrane Library were searched for relevant articles using MESH terms and keywords. Studies were included if they had reported quantitative estimates and standard deviations of the association between each weight loss drug and weight, with information on at least one cardiovascular risk factor. A total of eight trials (three orlistat and five sibutramine) with information on 1391 individuals was included in the present analysis. The mean decrease in weight between the intervention and control groups was 5.25 kg (95% confidence interval: 3.03–7.48) after a minimum follow‐up of 6 months. There was evidence of statistical heterogeneity between the studies (I2 = 76%) that was no longer apparent after exclusion of trials of orlistat (mean weight decrease = 5.32 kg; I2 = 38%). There was little evidence that treatment was associated with adverse effects on cardiovascular risk factors but this requires verification from future large trials with longer study follow‐up.
Url:
DOI: 10.1111/j.1467-789X.2009.00620.x
Affiliations:
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Huxley</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>The George Institute for International Health, the University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Obesity Reviews</title><title level="j" type="alt">OBESITY REVIEWS</title><idno type="ISSN">1467-7881</idno><idno type="eISSN">1467-789X</idno><imprint><biblScope unit="vol">11</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="150">150</biblScope><biblScope unit="page" to="158">158</biblScope><biblScope unit="page-count">9</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-02">2010-02</date></imprint><idno type="ISSN">1467-7881</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1467-7881</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescents obesity reviews</term><term>Adult populations</term><term>Adverse effects</term><term>Adverse event</term><term>Attrition rate</term><term>Authors journal compilation</term><term>Berkowitz</term><term>Blood pressure</term><term>Body mass index</term><term>Cardiovascular</term><term>Cardiovascular risk factors</term><term>Caucasian adolescents</term><term>Cochrane library</term><term>Control group</term><term>Control groups</term><term>Czernichow</term><term>Diastolic blood pressure</term><term>Excess weight</term><term>George institute</term><term>Heterogeneity</term><term>Insulin levels</term><term>International association</term><term>International health</term><term>Larger studies</term><term>Limited evidence</term><term>Mmhg</term><term>Mmol</term><term>Obese</term><term>Obese adolescents</term><term>Obesity</term><term>Obesity reviews</term><term>Orlistat</term><term>Orlistat ozkan</term><term>Orlistat therapy</term><term>Overall attrition rate</term><term>Overall estimate</term><term>Overweight adolescents</term><term>Placebo</term><term>Placebo group</term><term>Placebo groups</term><term>Potential publication bias</term><term>Public health</term><term>Publication bias</term><term>Pulse rate</term><term>Quantitative estimates</term><term>Randomized</term><term>Randomized trials</term><term>Relevant articles</term><term>Relevant references</term><term>Risk factors</term><term>Search strategy</term><term>Sibutramine</term><term>Sibutramine berkowitz</term><term>Small amount</term><term>Small increase</term><term>Standard deviation</term><term>Standard deviations</term><term>Statistical heterogeneity</term><term>Systolic blood pressure</term><term>Therapeutic lifestyle change</term><term>Total cholesterol</term><term>True effect</term><term>Waist circumference</term><term>Weight decrease</term><term>Weight loss</term><term>Weight loss agents</term><term>Weight loss drug</term><term>Weight loss drugs</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adolescents obesity reviews</term><term>Adult populations</term><term>Adverse effects</term><term>Adverse event</term><term>Attrition rate</term><term>Authors journal compilation</term><term>Berkowitz</term><term>Blood pressure</term><term>Body mass index</term><term>Cardiovascular</term><term>Cardiovascular risk factors</term><term>Caucasian adolescents</term><term>Cochrane library</term><term>Control group</term><term>Control groups</term><term>Czernichow</term><term>Diastolic blood pressure</term><term>Excess weight</term><term>George institute</term><term>Heterogeneity</term><term>Insulin levels</term><term>International association</term><term>International health</term><term>Larger studies</term><term>Limited evidence</term><term>Mmhg</term><term>Mmol</term><term>Obese</term><term>Obese adolescents</term><term>Obesity</term><term>Obesity reviews</term><term>Orlistat</term><term>Orlistat ozkan</term><term>Orlistat therapy</term><term>Overall attrition rate</term><term>Overall estimate</term><term>Overweight adolescents</term><term>Placebo</term><term>Placebo group</term><term>Placebo groups</term><term>Potential publication bias</term><term>Public health</term><term>Publication bias</term><term>Pulse rate</term><term>Quantitative estimates</term><term>Randomized</term><term>Randomized trials</term><term>Relevant articles</term><term>Relevant references</term><term>Risk factors</term><term>Search strategy</term><term>Sibutramine</term><term>Sibutramine berkowitz</term><term>Small amount</term><term>Small increase</term><term>Standard deviation</term><term>Standard deviations</term><term>Statistical heterogeneity</term><term>Systolic blood pressure</term><term>Therapeutic lifestyle change</term><term>Total cholesterol</term><term>True effect</term><term>Waist circumference</term><term>Weight decrease</term><term>Weight loss</term><term>Weight loss agents</term><term>Weight loss drug</term><term>Weight loss drugs</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Santé publique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Weight loss drugs have been developed to reduce the comorbidities associated with excess weight. We conducted a meta‐analysis of the efficacy of orlistat and sibutramine on weight, body mass index, waist circumference and cardiovascular risk factors in overweight adolescents. MEDLINE and the Cochrane Library were searched for relevant articles using MESH terms and keywords. Studies were included if they had reported quantitative estimates and standard deviations of the association between each weight loss drug and weight, with information on at least one cardiovascular risk factor. A total of eight trials (three orlistat and five sibutramine) with information on 1391 individuals was included in the present analysis. The mean decrease in weight between the intervention and control groups was 5.25 kg (95% confidence interval: 3.03–7.48) after a minimum follow‐up of 6 months. There was evidence of statistical heterogeneity between the studies (I2 = 76%) that was no longer apparent after exclusion of trials of orlistat (mean weight decrease = 5.32 kg; I2 = 38%). There was little evidence that treatment was associated with adverse effects on cardiovascular risk factors but this requires verification from future large trials with longer study follow‐up.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li></region><settlement><li>Bobigny</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Czernichow, S" sort="Czernichow, S" uniqKey="Czernichow S" first="S." last="Czernichow">S. Czernichow</name></region><name sortKey="Barzi, F" sort="Barzi, F" uniqKey="Barzi F" first="F." last="Barzi">F. Barzi</name><name sortKey="Baur, L A" sort="Baur, L A" uniqKey="Baur L" first="L. A." last="Baur">L. A. Baur</name><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><name sortKey="Greenfield, J R" sort="Greenfield, J R" uniqKey="Greenfield J" first="J. R." last="Greenfield">J. R. Greenfield</name><name sortKey="Huxley, R R" sort="Huxley, R R" uniqKey="Huxley R" first="R. R." last="Huxley">R. R. Huxley</name><name sortKey="Lee, C M Y" sort="Lee, C M Y" uniqKey="Lee C" first="C. M. Y." last="Lee">C. M. Y. Lee</name><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M." last="Woodward">M. Woodward</name></country><country name="France"><region name="Île-de-France"><name sortKey="Czernichow, S" sort="Czernichow, S" uniqKey="Czernichow S" first="S." last="Czernichow">S. Czernichow</name></region><name sortKey="Czernichow, S" sort="Czernichow, S" uniqKey="Czernichow S" first="S." last="Czernichow">S. Czernichow</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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